The story of eMurmur began in 2012 in Graz, Austria, a country most famous for Arnold Schwarzenegger, Mozart, the Sound of Music, Schnitzel and skiing. But what many don’t know is that Austria also has excellent higher education schools, one of them being the Graz University of Technology, and it is there where I, Andreas Schriefl, met my name twin and co-founder Andreas Reinisch, who was working on his MSc in Biomedical Engineering, after having completed a BSc in Computer Sciences. At the time we were both working on a research project focused on using automated image analysis for the purpose of extracting collagen fiber orientations from images of human arterial wall tissues.
I quickly realized that Andreas Reinisch was exceptionally smart, driven, and fun to work with, so I asked him if he wanted to collaborate on a heart murmur passion project I was working on during my few “off” hours in the evenings and on weekends. Andreas agreed and our journey began.
Picture: Founding moment taken on the day we formally incorporated in Austria. Founders: Reinisch (left) and myself (right).
A family member’s 1-month-old baby was diagnosed with a potentially pathological heart murmur by the family’s primary care provider, and referred for a heart ultrasound by an expert. In the end the “pathological murmur” turned out to be benign, but the weeks it took to receive the final diagnosis were understandably stressful and especially worrisome for us all. Experiencing the kind of stress and uncertainty this event caused, and having thought about the broader implications, triggered the idea of looking into better ways to objectively detect a murmur – sparing family the stress that comes along with uncertainty, and healthcare providers the stress of potentially missing something serious. At the time I had no idea if my idea would even work, and certainly could not have known the path it would send me down, but I knew I had to investigate the possibility and hopefully improve the 200 year old method of cardiac auscultation.
Myself and Andreas joined a local incubator called Science Park Graz that allowed us to work on early prototypes and get early exposure to the start-up world while still pursuing our studies full time. What followed was years of development, clinical work, grants from the Austrian government, private investments and team growth; and finally, us both taking the scary but exciting leap of quitting our day jobs! The company was formally incorporated by myself and Andreas Reinisch in December 2014 in Graz, Austria as Computational Signal Detection Laboratories, or CSD Labs GmbH. Later we would decide to do business under the product brand name eMurmur. During the next couple of years the company focused on further technology development and clinical studies for the real world validation of our algorithms, and won some prizes along the way.
In 2018 it became clear that the initial market entry would be in North America, and the company also incorporated in Canada to run marketing and sales. I chose Ottawa, Canada as our North American hub, not just because of its endless and frigid winters, but because it’s my wife’s hometown, and we quickly found a great community of support for eMurmur here. By mid 2018 we had grown to include a business and marketing team to support our expanded product line made up of the educational apps eMurmur Primer CE and eMurmur University, solutions that would revolutionize the way heart murmur recognition is being taught in schools.
But our biggest and hardest won milestone so far was still to come: 2019 was the year our heart murmur detection solution, eMurmur ID, finally received FDA and CE regulatory clearance. We are proud of how far we’ve come on this journey of many highs and lows, and are excited for all that is to come.
Nov 2019 | Johns Hopkins <> eMurmur ID study wins 1ST PLACE for value improvement project
Dr. Reid Thompson and colleagues from the Johns Hopkins University School of Medicine win 1st place for their value improvement project entitled "Reducing inappropriate use of echocardiography in children: screening heart murmurs with an AI-enabled stethoscope", in which they used eMurmur ID to explore how it could be used together with telemedicine to create a new paradigm to screen for pathologic heart murmurs in primary care settings.
View the award
August 15 , 2019 | Avkin, a wearable technology company for patient centered simulation, announces partnership with eMurmur
June 12 + 13, 2019 | eMurmur at Creative Destruction Lab's Super Session in Toronto, Canada
We are pleased to be part of the Creative Destruction Lab's Super Session 2019.
Creative Destruction Lab's Super Session is a two day event featuring keynote speakers, networking and a showcase of CDL's graduating early-stage tech companies.
Andreas our CEO and founder had the pleasure of addressing the CDL network of alumni, investors etc. on Thursday to share how far we've come since we graduated from CDL.
June 12, 2019 | eMurmur receives CE mark certification for its heart murmur detection solution
eMurmur® announced today that its flagship "eMurmur ID" solution has received the CE mark certification. Accreditation is an important part of the eMurmur business, which now carries the quality management certification ISO 13485:2016 and the EC certification according to the Medical Devices Directive 93/42/EEC. The news comes on the heels of eMurmur ID receiving FDA clearance, making it the only heart murmur detection solution that has received clearance for both the U.S. and European markets.
eMurmur ID is a mobile and cloud solution which operates in conjunction with a 3rd party electronic stethoscope. It uses advanced machine learning to identify and classify pathologic and innocent heart murmurs, the absence of a heart murmur, and S1, S2 heart sounds. The end-to-end solution is comprised of ML-based analytics, a mobile app, and a web portal. It supports the workflows of healthcare providers performing cardiac auscultation and has multiple applications including primary and specialty care, and corporate health.
Heart Murmur Detection: Past vs Future
Heart disease is the leading cause of death globally for both men and women, causing over 30% of all deaths annually. Heart auscultation (meaning "to listen with a stethoscope") is a 200+ year-old method to screen for heart disease by listening for abnormal heart sounds (murmurs), used worldwide for patients of all ages. However, heart auscultation is subjective in nature and studies have shown that accuracy rates amongst primary care providers are low. With an accuracy rate of over 85%, eMurmur ID makes expert-level auscultation accessible to any healthcare provider performing auscultation.
Early Access Program
The eMurmur ID technology has multiple areas of application including HMO networks, point of care clinics, executive health, pre-physicals, retail clinics, occupational health, rural health and telemedicine. eMurmur launched an early access program available at https://emurmur.com/clinical, designed to give early adopters full access to eMurmur ID.
Learn more here: https://www.prnewswire.com/news-releases/emurmur-receives-ce-mark-certification-for-its-heart-murmur-detection-solution-300866398.html
May 2019 | FDA grants clearance for eMurmur ID, heart murmur detection solution on a personal mobile device
May 7, 2019
eMurmur® today announced that its flagship “eMurmur ID” solution has received FDA clearance, enabling a new era in heart murmur detection. eMurmur ID is a mobile and cloud solution which operates in conjunction with a 3rd party electronic stethoscope. It uses advanced machine learning to identify and classify pathologic and innocent heart murmurs, the absence of a heart murmur, and S1, S2 heart sounds. The end-to-end solution is comprised of AI-based analytics, a mobile app, and a web portal (all HIPAA compliant). It supports the workflows of healthcare providers performing cardiac auscultation and has multiple applications including primary and specialty care, and corporate health.
Heart Murmur Detection: Past vs Future
Heart disease is the leading cause of death globally for both men and women, causing 31% of all deaths annually. Heart auscultation (meaning “to listen with a stethoscope”) is a 200+ year-old method to screen for heart disease by listening for abnormal heart sounds (murmurs), used worldwide for patients of all ages. However, heart auscultation is subjective in nature and studies have shown accuracy rates amongst primary care providers to be as low as 20-25%. With an accuracy rate of over 85%, eMurmur ID makes expert-level auscultation accessible to any healthcare provider performing auscultation.
“The eMurmur ID solution has the potential to disrupt medical care”, said Dr. Derek Exner, Professor and Canada Research Chair in Cardiovascular Clinical Trials at the University of Calgary. “The evidence for its utility is solid and includes five studies on over 1000 patients, including blinded, multi-centre trials. This system has been shown to be accurate, informative, and easy-to-use. It provides healthcare professionals with a potent screening tool and method to confirm their clinical diagnoses, enhancing patient care.”
“Receiving FDA clearance marks a significant milestone in our company’s history, and I’m very excited to finally be able to take the eMurmur ID solution to market,” said Andreas Schriefl, co-founder and CEO of eMurmur. “We believe that eMurmur ID has the potential to disrupt the status-quo of heart murmur screening and significantly reduce costs to healthcare systems worldwide.”
“From a technology perspective, receiving FDA clearance requires solid clinical proof of the algorithm performance characteristics, as well as a quality and risk management system that ensures patient safety and compliance with stringent regulatory standards,” said Andreas Reinisch, co-founder and CTO of eMurmur. “Through this process, our company has gained significant knowledge and expertise to facilitate and support future AI- based medical solutions,”
About eMurmur (www.emurmur.com)
Founded in 2014, eMurmur is a privately-held medical technology company specializing in Machine Learning for the analysis of data for medical applications. eMurmur is the leader in automated heart murmur detection technology and has completed multiple prospective clinical studies in this field, demonstrating expert-level accuracy rates. In addition, the company’s intellectual property includes a proprietary database of 1000s of heart recordings with corresponding gold-standard echocardiogram diagnoses and cardiologist assessments. eMurmur also provides heart-auscultation educational solutions to leading medical schools. The company is headquartered in Ottawa, Canada (CSD Labs International), has R&D operations in Graz, Austria (CSD Labs), and does business under the name eMurmur.
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April 2019 | eMurmur releases Primer, accredited by Partners in Healthcare Education, LLC, accredited by the American Association of Nurse Practitioners
This month, we launched eMurmur Primer, an accredited app designed for nurse practitioners and nurses to improve their cardiac auscultation skills while earning continuing education credits. Creating an interactive and practical app for nurses took several months of development as we worked closely with several nurse practitioners and nurses to identify what they wanted in an app. We took their feedback to heart and used the library of 1,000 cardiologists-vetted, patient heart sounds from our clinical trials to design an app that would prime their cardiac auscultation skills. We partnered with top medical institutions to gather our research and design a straightforward continuing education course for use by any busy nurse. In one recent survey, we found that 7/10 nurses were not confident in identifying benign or pathological heart murmurs. To improve confidence in hearing heart murmurs and understanding the heart, we designed Primer based on the 3 Keys to Mastering Cardiac Auscultation by Cardiologist John P. Finley in his book Teaching Heart Auscultation to Health Professionals.
Download our app for free to understand heart anatomy, identify normal heart sounds versus abnormal, the difference between benign and pathological murmurs, and differentiate between murmurs that warrant further evaluation and those that do not with eMurmur Primer.
eMurmur Primer is accredited by Partners in Healthcare Education, LLC, accredited by the American Association of Nurse Practitioners
March 2019 | eMurmur Heartpedia launches in the Google Play and Apple App Store
Today, eMurmur announced the release of eMurmur Heartpedia, an app designed to help patients, parents and medical professionals to better understand heart defects through anatomically-correct 3D models and corresponding heart and murmur sound recordings for each defect. eMurmur Heartpedia is a major upgrade of the original Heartpedia app from Cincinnati Children’s Hospital Medical CenterCentre which has been downloaded over 100,000 times since its release in 2014.
"Congenital heart defects can be difficult to visualize, understand, and explain. Supplying easy-to-understand information on heart defects and established surgical repair strategies can result in improved comprehensive care for the patient,” says Peace Madueme, MD MS FAAP FACC FASE at Nemours Children’s Hospital in Orlando. "eMurmur Heartpedia is unique in that it provides validated patient heart sounds, 3D cardiac models and videos in an easy- to- use app that is accessible and understandable by anyone."
“The rich visual and audio heart information in eMurmur Heartpedia make it much easier to understand heart defects, which we expect will be invaluable to families, healthcare professionals, medical and nursing schools.” says Andreas Schriefl, founder and CEO of eMurmur
eMurmur Heartpedia is a downloadable app that runs on a mobile device such as a smartphone or tablet, and is available from both the IOS and Android app stores. Check out eMurmur Heartpedia in the Google Play and Apple App store.
Dec 2018 | Johns Hopkins study demonstrates 88% accuracy of eMurmur, as published in Pediatric Cardiology
Results from a study called "Artificial Intelligence-Assisted Auscultation of Heart Murmurs: Validation by Virtual Clinical Trial" have been published in the peer-reviewed journal of Pediatric Cardiology. This is the first reported comprehensive and objective evaluation of an AI-based murmur detection algorithm, and included 3180 heart sound recordings from 603 outpatient visits. Algorithm estimation of heart rate was similar to gold standard. Sensitivity and specificity for detection of pathologic cases were 93% (CI 90–95%) and 81% (CI 75–85%), respectively, with accuracy 88% (CI 85–91%). In conclusion, the eMurmur algorithm tested has high sensitivity and specificity for detection of pathologic murmurs, similar to levels reported for specialist auscultation, making it a potentially useful screening tool for heart disease.
Read the publication
Aug 2018 | eMurmur ID filed for FDA 510(k) and CE regulatory clearance
eMurmur announced today that it has submitted its clinical screening software tool to the US Federal Drug Administration (FDA) as part of an application for FDA 510(k) clearance. This filing is in addition to eMurmur’s application and filing for European CE regulatory clearance which was submitted in June 2018.
Jun 2018 | eMurmur graduates from Creative Destruction Labs
eMurmur announced today that it has successfully graduated from the Creative Destruction Labs (CDL), a highly competitive and successful seed-stage program for massively scalable, science-based companies. eMurmur participated in the 9-month program as part of the CDL-West’s health stream.
May 2018 | Dr. Derek Exner joins eMurmur as a medical advisor
eMurmur announces that renowned cardiologist, Dr. Derek Exner, Professor has joined its advisory board. Dr. Exner is Canada Research Chair, Cardiovascular Clinical Trials; Associate Dean, Clinical Trials, Cumming School of Medicine; and Professor, Department of Cardiac Sciences and Community Health Sciences, University of Calgary.
Feb 2018 | eMurmur opens North American sales and marketing office in Ottawa, Canada
eMurmur announced today that it has incorporated in Canada and opened an office in Ottawa to address the North America market in order to begin to build out its sales, marketing and market development team. eMurmur will continue to operate and grow its R&D facilities in Graz, Austria.
Nov 2017 | Data from comparative clinical study presented at AHA Scientific Sessions 2017
Dr. Lillian Lai of Children’s Hospital Eastern Ottawa presented a study today titled “Performance Evaluation of Two Heart Murmur Detection Applications by Prospective Clinical Trial” at the AHA Scientific Session 2017 today.
The study included 93 patients and demonstrated a sensitivity and specificity for automated detection of pathologic murmurs of 84.4% and 85.9%, respectively, with the gold standard being echocardiography, with eMurmur significantly outperform the other device.
Read the abstract
Read more on Business Wire
Nov 2017 | Results from Johns Hopkins study presented at AHA Scientific Sessions 2017
In the AHA Scientific Session “Best Abstracts in Health Tech ”, Dr. W. Reid Thompson, associate professor of pediatrics at Johns Hopkins University, today presented a study titled “Validation of a Heart Murmur Algorithm by Virtual Clinical Trial” which used the eMurmur algorithm to blindly analyze 3,180 heart sound recordings from the Johns Hopkins Cardiac Auscultatory Recording Database (CARD). Study results showed a sensitivity of 93% and a specificity of 81%, as well as an accuracy of 88%.
Read the Abstract
Read more on Business Wire
July 2017 | eMurmur’s heart murmur detection algorithm scores 89% sensitivity in an elderly population clinical trial
eMurmur announces completion of a clinical trial evaluating the performance of its heart murmur detection algorithms on an elderly population with congenital heart disease. The algorithm’s sensitivity for autonomous detection of pathologic murmurs was 89%. No high severity cases were missed by the algorithm. Further, it yielded accurate heart rate estimation and S1/S2 detection, despite the presence of significant environmental noise.
Read the abstract
Nov 2016 | eMurmur’s heart murmur detection algorithm scores 94% accuracy in clinical pilot study
eMurmur announces impressive pilot study of its AI platform on 106 children at Children’s Hospital of Eastern Ontario, Canada, where it differentiated pathologic from innocent heart murmurs with high sensitivity (87%) and specificity (100%), a positive predictive value of 100%, a negative predictive value of 90%, and high accuracy (94%) when compared with echocardiography as the gold standard for diagnosing murmurs.
Read more on Business Wire
Read the publication
Oct 2016 | Dr. Andrew Redington joins as a medical advisor
eMurmur announces Andrew Redington, MD, an internationally renowned cardiologist and Chief of Pediatric Cardiology at Cincinnati Children’s Hospital in Ohio, United States, joins the company as a medical advisor.
Read more on Business Wire
May 2016 | Dr. Lillian Lai joins as a medical advisor
eMurmur announces that Lillian Lai, MD, Cardiologist at Children's Hospital of Eastern Ontario, Canada joins the company as a medical advisor. Dr. Lai previously served as a Principal Investigator on several clinical studies for the development and validation of the eMurmur technology.
Feb 2016 | eMurmur recipient of major Austrian government funding
eMurmur approved to receive up to EUR 600,000 in Seed financing from the Austrian government, aimed to help transform well formulated business ideas around innovative technologies into a start-up ready for market entry.
July 2015 | eMurmur awarded prestigious European Horizon 2020 research grant
The European Commission awards a prestigious EUR 50,000 Horizon 2020 grant to eMurmur to advance its R&D into a clinically tested mobile-based technology for the objective detection and classification of heart murmurs.
May 2015 | eMurmur wins Best of Biotech business plan competition
eMurmur wins the special MedTech award at the seventh international business plan competition "Best of Biotech". The competition awards excellence in the areas of life science and medical technology, is organised by Austria Wirtschaftsservice and commissioned by the Austrian Federal Ministry of Science, Research and Economy. A total of 30 projects with economic potential from six countries were selected by an international jury comprised of experts from the fields of industry, finance and economics. eMurmur was awarded a prestigious prize worth EUR 10,000.
Dec 2014 | eMurmur founded in Graz, Austria, and first round of angel investments
CSD Labs GmbH (d.b.a. eMurmur) was formally founded in Graz, Austria with the vision of leveraging state-of-the art signal processing, machine learning, and high quality clinical datasets to create an autonomous heart murmur detection AI. Additionally, eMurmur raises EUR 420,000 from US angel investors.
Jul 2013 | Founders receive prestigious Start-up grant from Austrian government
Founders Andreas Schriefl (PhD Physicist / Biomedical Engineer) and Andreas Reinisch (Computer Science & Biomedical Engineer) receive a prestigious start-up grant of EUR 210,000 from the Austrian government, rewarded to promising high-tech ideas with high-growth potential to allow for preliminary feasibility work on heart sound analysis and development of a business plan around the founders’ vision.